PQ 69

Names

[ Name ]:
PQ 69

[Synonym ]:
3H-Pyrazolo[4,3-c]quinolin-3-one, 4-(butylamino)-2-(3-fluorophenyl)-1,2-dihydro-
MFCD30182281
4-(Butylamino)-2-(3-fluorophenyl)-1,2-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one

Biological Activity

[Description]:

PQ-69 is a potent and selective adenosine A1 receptor antagonist with inverse agonist activity. PQ-69 binds to hA1 receptor with a Ki value of 0.96 nM, is 217-fold more selective compared with hA2A receptors (Ki=208 nM) and >1,000-fold selectivity over hA3 receptor (Ki >100 μM). PQ-69 can be used for the research of renal dysfunction[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor

[References]

[1]. Min Lu, et al. PQ-69, a novel and selective adenosine A1 receptor antagonist with inverse agonist activity. Purinergic Signal. 2014 Dec;10(4):619-29.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
553.1±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₁₉FN₄O

[ Molecular Weight ]:
350.39

[ Flash Point ]:
288.3±32.9 °C

[ Exact Mass ]:
350.154297

[ LogP ]:
3.64

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.674

Related Compounds

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