GeA-69

Names

[ Name ]:
GeA-69

Biological Activity

[Description]:

GeA-69 is a selective, highly cell permeable allosteric inhibitor of poly-adenosine-diphosphate-ribose polymerase 14 (PARP14) targeting macrodomain 2, with a Kd of 2.1 µM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> PARP

Signaling Pathways >> Cell Cycle/DNA Damage >> PARP

[Target]

PARP14:2.1 μM (Kd)

[References]

[1]. Schuller M, et al. Discovery of a Selective Allosteric Inhibitor Targeting Macrodomain 2 of Polyadenosine-Diphosphate-Ribose Polymerase 14. ACS Chem Biol. 2017 Nov 17;12(11):2866-2874.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₁₆N₂O

[ Molecular Weight ]:
300.35

[ Storage condition ]:
2-8℃

Related Compounds

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