ARD-69

Names

[ Name ]:
ARD-69

Biological Activity

[Description]:

ARD-69 (compound 34) is a potent PROTAC androgen receptor degrader. ARD-69 induces degradation of androgen receptor (AR) protein in AR-positive prostate cancer cell lines. ARD-69 suppresses AR-regulated gene expression[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC

Signaling Pathways >> Others >> Androgen Receptor

[Target]

Androgen receptor (AR)[1] PROTAC[1]

[References]

[1]. Han X, et al. Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer. J Med Chem. 2019 Jan 10.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆₂H₇₄ClFN₈O₇S

[ Molecular Weight ]:
1129.82

Related Compounds

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