Broussonin E

Names

[ Name ]:
Broussonin E

[Synonym ]:
Phenol, 5-[3-(2-hydroxy-4-methoxyphenyl)propyl]-2-methoxy-
5-[3-(2-Hydroxy-4-methoxyphenyl)propyl]-2-methoxyphenol

Biological Activity

[Description]:

Broussonin E is a phenolic compound and shows anti-inflammatory activity. Broussonin E can suppress inflammation by modulating macrophages activation statevia inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathway. Broussonin E can be used for the research of inflammation-related diseases such as atherosclerosis[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> STAT

Signaling Pathways >> JAK/STAT Signaling >> JAK

Signaling Pathways >> Epigenetics >> JAK

Signaling Pathways >> Stem Cell/Wnt >> JAK

Signaling Pathways >> JAK/STAT Signaling >> STAT

Signaling Pathways >> Immunology/Inflammation >> Interleukin Related

Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Immunology/Inflammation >> COX

Signaling Pathways >> MAPK/ERK Pathway >> ERK

Signaling Pathways >> Immunology/Inflammation >> Arginase

Signaling Pathways >> Stem Cell/Wnt >> ERK

[Target]

ERK

p38 MAPK

JAK2

STAT3

IL-1β

IL-6

COX-2

IL-10

[In Vitro]

Broussonin E (20 μM, 3 h) 抑制 LPS (Lipopolysaccharides，HY-D1056) 刺激的磷酸化 ERK 和 p38 MAPK[1]。 Broussonin E 可激活 janus 激酶 (JAK) 2、信号转导和转录激活因子 (STAT) 3[1]。 Broussonin E (0-20 μM, 3 h) 可抑制 RAW264.7 细胞中 LPS 诱导的促炎产生，包括 TNF-α、IL-1β、IL-6、COX-2 和 iNOS[1 ]. Broussonin E 增强 LPS 刺激的 RAW264.7 细胞中抗炎介质如 IL-10、CD206 和精氨酸酶-1 (Arg-1) 的表达[1]。 Western Blot Analysis[1] Cell Line: RAW264.7 cells Concentration: 2.5, 5, 10 and 20 Incubation Time: 3 h Result: Inhibited p-ERK and p-p38 MAPK, but not p-JNK MAPK expression in LPS-stimulated RAW264.7 cells.

[References]

[1]. Huang SP, et al. Broussonin E suppresses LPS-induced inflammatory response in macrophages via inhibiting MAPK pathway and enhancing JAK2-STAT3 pathway. Chin J Nat Med. 2019 May 20;17(5):372-380.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
464.9±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₂₀O₄

[ Molecular Weight ]:
288.338

[ Flash Point ]:
235.0±27.3 °C

[ Exact Mass ]:
288.136169

[ PSA ]:
58.92000

[ LogP ]:
3.35

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.586

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.