Thioredoxin reductase

Names

[ Name ]:
Thioredoxin reductase

[Synonym ]:
1H-Indole, 3,3'-[4-(trifluoromethyl)-2,6-pyridinediyl]bis[6-bromo-1-[(4-methylphenyl)sulfonyl]-
3,3'-[4-(Trifluoromethyl)-2,6-pyridinediyl]bis{6-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indole}
MFCD00678149
3,3'-[4-(trifluoromethyl)pyridine-2,6-diyl]bis{6-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indole}

Biological Activity

[Description]:

Thioredoxin reductase (TrxR) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
912.0±75.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₆H₂₄Br₂F₃N₃O₄S₂

[ Molecular Weight ]:
843.527

[ Flash Point ]:
505.3±37.1 °C

[ Exact Mass ]:
840.952698

[ LogP ]:
11.64

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.686

[ Storage condition ]:
-20°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ RIDADR ]:
NONH for all modes of transport

Articles

Design, synthesis, anti-schistosomal activity and molecular docking of novel 8-hydroxyquinoline-5-sufonyl 1,4-diazepine derivatives.

Bioorg. Chem. 46 , 17-25, (2013)

Schistosomiasis remains one of the most prevalent parasitic infections and has significant public health consequences. Praziquantel (PZQ) is the only drug currently administrated to treat this disease...

Compensating for the absence of selenocysteine in high-molecular weight thioredoxin reductases: the electrophilic activation hypothesis.

Biochemistry 53(4) , 664-74, (2014)

Mammalian thioredoxin reductase (TR) is a pyridine disulfide oxidoreductase that uses the rare amino acid selenocysteine (Sec) in place of the more commonly used amino acid cysteine (Cys). Selenium is...

Why is mammalian thioredoxin reductase 1 so dependent upon the use of selenium?

Biochemistry 53(3) , 554-65, (2014)

Cytosolic thioredoxin reductase 1 (TR1) is the best characterized of the class of high-molecular weight (Mr) thioredoxin reductases (TRs). TR1 is highly dependent upon the rare amino acid selenocystei...