Carebastine

Names

[ Name ]:
Carebastine

[Synonym ]:
p-(4-(4-(Diphenylmethoxy)piperidino)butyryl)-a-methylhydratropic Acid
Carebastinum
carebastine
2-(4-{4-[4-(Diphenylmethoxy)piperidin-1-yl]butanoyl}phenyl)-2-methylpropanoic acid
4-(4-(4-(Diphenylmethoxy)-1-piperidinyl)-1-oxobutyl)-a,a-dimethylbenzeneacetic Acid
Benzeneacetic acid, 4-[4-[4-(diphenylmethoxy)-1-piperidinyl]-1-oxobutyl]-α,α-dimethyl-
Carebastina
C32H37NO4
UNII-75DLN707DO
2-(4-{4-[4-(Diphenylmethoxy)-1-piperidinyl]butanoyl}phenyl)-2-methylpropanoic acid

Biological Activity

[Description]:

Carebastine is the active metabolite of Ebastine. Carebastine is a histamine H1 receptor antagonist. Carebastine inhibits VEGF-induced HUVEC and HPAEC proliferation, migration and angiogenesis in a dose-dependent manner[1]. Carebastine suppresses the expression of macrophage migration inhibitory factor[2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor

Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[Target]

H1 receptor

[References]

[1]. De Luisi A, et al. Anti-angiogenic activity of carebastine: a plausible mechanism affecting airway remodelling. Eur Respir J. 2009 Oct;34(4):958-66.

[2]. Zhao Y, et al. Carebastine, an H1-receptor antagonist, suppresses the expression of macrophage migration inhibitory factor. Clin Exp Dermatol. 2008 Nov;33(6):785-7.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
657.9±55.0 °C at 760 mmHg

[ Melting Point ]:
178-180ºC

[ Molecular Formula ]:
C₃₂H₃₇NO₄

[ Molecular Weight ]:
499.641

[ Flash Point ]:
351.7±31.5 °C

[ Exact Mass ]:
499.272247

[ PSA ]:
66.84000

[ LogP ]:
6.09

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.609

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.