Phosphodiesterase II

Names

[ Name ]:
Phosphodiesterase II

[Synonym ]:
MFCD00131884

Biological Activity

[Description]:

Phosphodiesterase II, namely phosphodiesterase 2, is mainly involved in the hydrolysis of the important second messengers cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), and is often used in biochemical research. Phosphodiesterase II is expressed in a variety of tissues, such as the adrenal medulla, brain, heart, platelets, macrophages and endothelial cells, and is involved in the regulation of many different intracellular processes[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)

Research Areas >> Neurological Disease

[References]

[1]. Chong Zhang, et al. The roles of phosphodiesterase 2 in the central nervous and peripheral systems. Curr Pharm Des. 2015;21(3):274-90.

Chemical & Physical Properties

[ Storage condition ]:
−20°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ RIDADR ]:
NONH for all modes of transport

Articles

PdeH, a high-affinity cAMP phosphodiesterase, is a key regulator of asexual and pathogenic differentiation in Magnaporthe oryzae.

PLoS Pathog. 6(5) , e1000897, (2010)

Cyclic AMP-dependent pathways mediate the communication between external stimuli and the intracellular signaling machinery, thereby influencing important aspects of cellular growth, morphogenesis and ...

The role of cyclic nucleotide phosphodiesterases in the regulation of adipocyte lipolysis.

J. Lipid Res. 46(3) , 494-503, (2005)

This study assessed the effects of selective inhibitors of 3',5'-cyclic nucleotide phosphodiesterases (PDEs) on adipocyte lipolysis. IC224, a selective inhibitor of type 1 phosphodiesterase (PDE1), su...

Identification of bifunctional GA and AG intrastrand crosslinks formed between cisplatin and DNA.

J. Inorg. Biochem. 99(2) , 552-9, (2005)

A combination of enzymatic digestion and electrospray ionisation mass spectrometry (ESI-MS) was used to characterise bifunctional adducts in which cisplatin is bound to GA base sequences in 8mer and 1...

Related Compounds

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