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SMBA 1

Names

[ CAS No. ]:
906440-37-7

[ Name ]:
SMBA 1

[Synonym ]:
2-[(E)-(2-Nitro-9H-fluoren-9-ylidene)methyl]phenol
MFCD29079013
Phenol, 2-[(E)-(2-nitro-9H-fluoren-9-ylidene)methyl]-
2-[(2-Nitro-9H-fluorene-9-ylidene)methyl]phenol
2-[(2-Nitro-9H-fluoren-9-ylidene)methyl]-phenol
SMBA1

Biological Activity

[Description]:

A potent, and selective Bax agonist (Ki=43.3 nM) that induces conformational changes in Bax by blocking S184 phosphorylation; shows no affinity for other Bcl2 family members, including Bcl2, Bcl-XL, Mcl-1, Bcl-w, Bfl-1/A1, Bid or Bak; facilitates Bax insertion into mitochondrial membranes and forming Bax oligomers, leads to cytochrome c release and apoptosis in human lung cancer cells; potently suppresses lung tumour growth via apoptosis by selectively activating Bax in vivo without significant normal tissue toxicity.

[References]

References 1. Xin M, et al. Nat Commun. 2014 Sep 17;5:4935. 2. Daniele S, et al. ACS Chem Neurosci. 2017 Apr 11. doi: 10.1021/acschemneuro.7b00023. 3. Li R, et al. Cancer Res. 2017 Jun 1;77(11):3001-3012. 4. Levesley J, et al. Neuro Oncol. 2017 Jul 20. doi: 10.1093/neuonc/nox134. View Related Products by Target Bcl-2

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
502.0±38.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H13NO3

[ Molecular Weight ]:
315.322

[ Flash Point ]:
205.3±15.2 °C

[ Exact Mass ]:
315.089539

[ LogP ]:
7.65

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.757

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds