906440-37-7

906440-37-7 structure

Name: SMBA 1
Chemical Name: SMBA1
CAS Number: 906440-37-7
Molecular Formula: C₂₀H₁₃NO₃
Molecular Weight: 315.322
Catalog: Signaling Pathways Apoptosis Bcl-2 Family
Create Date: 2020-01-11 09:57:05
Modify Date: 2024-01-08 20:39:04
A potent, and selective Bax agonist (Ki=43.3 nM) that induces conformational changes in Bax by blocking S184 phosphorylation; shows no affinity for other Bcl2 family members, including Bcl2, Bcl-XL, Mcl-1, Bcl-w, Bfl-1/A1, Bid or Bak; facilitates Bax insertion into mitochondrial membranes and forming Bax oligomers, leads to cytochrome c release and apoptosis in human lung cancer cells; potently suppresses lung tumour growth via apoptosis by selectively activating Bax in vivo without significant normal tissue toxicity.

Name	SMBA1
Synonyms	2-[(E)-(2-Nitro-9H-fluoren-9-ylidene)methyl]phenol MFCD29079013 Phenol, 2-[(E)-(2-nitro-9H-fluoren-9-ylidene)methyl]- 2-[(2-Nitro-9H-fluorene-9-ylidene)methyl]phenol 2-[(2-Nitro-9H-fluoren-9-ylidene)methyl]-phenol SMBA1

Description	A potent, and selective Bax agonist (Ki=43.3 nM) that induces conformational changes in Bax by blocking S184 phosphorylation; shows no affinity for other Bcl2 family members, including Bcl2, Bcl-XL, Mcl-1, Bcl-w, Bfl-1/A1, Bid or Bak; facilitates Bax insertion into mitochondrial membranes and forming Bax oligomers, leads to cytochrome c release and apoptosis in human lung cancer cells; potently suppresses lung tumour growth via apoptosis by selectively activating Bax in vivo without significant normal tissue toxicity.
References	References 1. Xin M, et al. Nat Commun. 2014 Sep 17;5:4935. 2. Daniele S, et al. ACS Chem Neurosci. 2017 Apr 11. doi: 10.1021/acschemneuro.7b00023. 3. Li R, et al. Cancer Res. 2017 Jun 1;77(11):3001-3012. 4. Levesley J, et al. Neuro Oncol. 2017 Jul 20. doi: 10.1093/neuonc/nox134. View Related Products by Target Bcl-2

RIDADR	NONH for all modes of transport