Galactofucan

Names

[ Name ]:
Galactofucan

Biological Activity

[Description]:

Galactofucan (Fucogalactan) is a sulfated polysaccharide. Galactofucan can be extracted from brown seaweed Saccharina longicruris with anticoagulant, anti-tumor, anti-thrombosis, anti-inflammatory and antiviral properties. Galactofucan shows antiviral activities to HSV-1 and HSV-2 with IC50s of 0.76 and 1.34 µg/mL, respectively. Galactofucan can be used for the research of cancer and inflammation[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Anti-infection >> HSV

Research Areas >> Inflammation/Immunology

[Target]

HSV-1:0.76 μg/mL (IC50)

HSV-2:1.34 μg/mL (IC50)

[In Vitro]

Galactofucan (0-100 µg/mL; 48 h) shows antiviral activities towards HSV-1 and HSV-2 with IC50s of 0.76 and 1.34 µg/mL, respectively[1].

[In Vivo]

Galactofucan (10-100 mg/kg; i.p. once) (extracted from Agaricus bisporus) shows anti-inflammatory activity[2]. Animal Model: Male Swiss mice with acetic acid intraperitoneal injection[2] Dosage: 10, 30 and 100 mg/kg Administration: Intraperitoneal injection; 10-100 mg/kg once Result: Repressed acetic acid-induced abdominal constriction, inhibited leukocytes migration and peritoneal capillary permeability.

[References]

[1]. Ponce NMA, et al. Fucoidans from the phaeophyta Scytosiphon lomentaria: Chemical analysis and antiviral activity of the galactofucan component. Carbohydr Res. 2019 May 15;478:18-24.

[2]. Komura DL, et al. Structure of Agaricus spp. fucogalactans and their anti-inflammatory and antinociceptive properties. Bioresour Technol. 2010 Aug;101(15):6192-9.

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds

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