cytochrome p450 reductase

Names

[ Name ]:
cytochrome p450 reductase

[Synonym ]:
MFCD01093329

Biological Activity

[Description]:

Cytochrome P450 reductase is a NADPH-cytochrome reductase. Cytochrome P450 reductase has a role in promoting aromatase conformation optimal for substrate binding[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450

Research Areas >> Others

[References]

[1]. Chao Zhang, et al. Effector role of cytochrome P450 reductase for androstenedione binding to human aromatase. Int J Biol Macromol. 2020 Dec 1:164:510-517.

Chemical & Physical Properties

[ Storage condition ]:
20°C

Safety Information

[ Hazard Codes ]:
C

[ RIDADR ]:
NONH for all modes of transport

Articles

The central role of mosquito cytochrome P450 CYP6Zs in insecticide detoxification revealed by functional expression and structural modelling.

Biochem. J. 455(1) , 75-85, (2013)

The resistance of mosquitoes to chemical insecticides is threatening vector control programmes worldwide. Cytochrome P450 monooxygenases (CYPs) are known to play a major role in insecticide resistance...

The role of renal proximal tubule P450 enzymes in chloroform-induced nephrotoxicity: utility of renal specific P450 reductase knockout mouse models.

Toxicol. Appl. Pharmacol. 272(1) , 230-7, (2013)

The kidney is a primary target for numerous toxic compounds. Cytochrome P450 enzymes (P450) are responsible for the metabolic activation of various chemical compounds, and in the kidney are predominan...

Production of human cytochrome P450 2D6 drug metabolites with recombinant microbes--a comparative study.

Biotechnol. J. 7(11) , 1346-58, (2012)

The processes of drug development require efficient strategies to produce the respective drug metabolites, which are often difficult to obtain. Biotransformations employing recombinant microorganisms ...