Tryptophanase

Names

[ Name ]:
Tryptophanase

[Synonym ]:
MFCD00130539
1-(3-C-Ethynylpentofuranosyl)-2,4(1H,3H)-pyrimidinedione
2,4(1H,3H)-Pyrimidinedione, 1-(3-C-ethynylpentofuranosyl)-

Biological Activity

[Description]:

Tryptophanase, a bacterial enzyme, catalyzes degradation of tryptophan to indole, pyruvate and ammonia[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Rety S, et al. Structure of Escherichia coli tryptophanase purified from an alkaline-stressed bacterial culture. Acta Crystallogr F Struct Biol Commun. 2015 Nov;71(Pt 11):1378-83.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Molecular Formula ]:
C₁₁H₁₂N₂O₆

[ Molecular Weight ]:
268.223

[ Exact Mass ]:
268.069550

[ LogP ]:
0.02

[ Index of Refraction ]:
1.680

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Inhibition of Escherichia coli tryptophan indole-lyase by tryptophan homologues.

Arch. Biochem. Biophys. 560 , 20-6, (2014)

We have designed, synthesized and evaluated homotryptophan analogues as possible mechanism-based inhibitors for Escherichia coli tryptophan indole-lyase (tryptophanase, TIL, E.C. 4.1.99.1). As a quino...

Reaction pathway of tryptophanase-catalyzed L-tryptophan synthesis from D-serine.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 879(29) , 3289-95, (2011)

Tryptophanase, L-tryptophan indole-lyase with extremely absolute stereospecificity, can change the stereospecificity in concentrated diammonium hydrogenphosphate solution. While tryptophanase is not i...

Indole production by the tryptophanase TnaA in Escherichia coli is determined by the amount of exogenous tryptophan.

Microbiology 159(Pt 2) , 402-10, (2013)

The signalling molecule indole occurs in significant amounts in the mammalian intestinal tract and regulates diverse microbial processes, including bacterial motility, biofilm formation, antibiotic re...