asparaginase

Names

[ Name ]:
asparaginase

[Synonym ]:
IUB: 3.5.4.4
Benzisothiazolone
L-ASPARAGINASE
T56 BSMVJ
ASPARAGINASE
benzo[d]isothiazol-3-one
1,2-Benzisothiazol-3(2H)-one
EC 3.5.1.1
T56 BSNJ DQ
crasnitin
L-ASPARAGINE AMIDOHYDROLASE
1,2-Benzothiazol-3(2H)-one
elspar
1,2-Benzisothiazol-3-ol
1,2-Benzothiazol-3-ol
Benzisothiazolone (BIT)
colaspase

Biological Activity

[Description]:

L-Asparaginase (L-ASNase), a hydrolase that catalyzes the conversion of L-asparagine, used in acute lymphoblastic leukemia treatment. L-Asparaginase depletes L-asparagine from plasma resulting in inhibition of RNA and DNA synthesis with the subsequent blastic cell apoptosis[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Piatkowska-Jakubas B, et al. Use of L-asparaginase in acute lymphoblastic leukemia: recommendations of the Polish Adult Leukemia Group. Pol Arch Med Wewn. 2008 Nov;118(11):664-9.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
204.5±23.0 °C at 760 mmHg

[ Molecular Formula ]:
C₇H₅NOS

[ Molecular Weight ]:
151.186

[ Flash Point ]:
77.5±22.6 °C

[ Exact Mass ]:
151.009186

[ LogP ]:
1.78

[ Vapour Pressure ]:
0.2±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.745

[ Storage condition ]:
2-8°C

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H317-H361

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T,Xn

[ Risk Phrases ]:
61-42/43-63

[ Safety Phrases ]:
53-22-36/37/39-45-36/37

[ RIDADR ]:
3249

[ WGK Germany ]:
3

[ RTECS ]:
CI9000000

[ Packaging Group ]:
II

Articles

Complete sequencing and characterization of 21,243 full-length human cDNAs.

Nat. Genet. 36 , 40-5, (2004)

As a base for human transcriptome and functional genomics, we created the "full-length long Japan" (FLJ) collection of sequenced human cDNAs. We determined the entire sequence of 21,243 selected clone...

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res. 14 , 2121-7, (2004)

The National Institutes of Health's Mammalian Gene Collection (MGC) project was designed to generate and sequence a publicly accessible cDNA resource containing a complete open reading frame (ORF) for...

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

Anal. Chem. 81(11) , 4493-501, (2009)

The analysis of proteome-wide phosphorylation events is still a major analytical challenge because of the enormous complexity of protein phosphorylation networks. In this work, we evaluate the complem...

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.