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PF-3274167

Names

[ CAS No. ]:
900510-03-4

[ Name ]:
PF-3274167

[Synonym ]:
Pyridine, 5-[3-[3-(2-chloro-4-fluorophenoxy)-1-azetidinyl]-5-(methoxymethyl)-4H-1,2,4-triazol-4-yl]-2-methoxy-
pf 3274167
5-{3-[3-(2-Chloro-4-fluorophenoxy)-1-azetidinyl]-5-(methoxymethyl)-4H-1,2,4-triazol-4-yl}-2-methoxypyridine
PF-3274167

Biological Activity

[Description]:

Cligosiban (PF-3274167) is a high-affinity nonpeptide oxytocin receptor (OTR) antagonist, with Ki of 9.5 nM.IC50 value: 9.5 nM [1]Target: oxytocin receptor (OTR)

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Oxytocin Receptor
Research Areas >> Endocrinology

[References]

[1]. Karpenko IA, et al. Selective nonpeptidic fluorescent ligands for oxytocin receptor: design, synthesis, and application to time-resolved FRET binding assay. J Med Chem. 2015 Mar 12;58(5):2547-2552.

[2]. Brown A, et al. Triazole oxytocin antagonists: Identification of an aryloxyazetidine replacement for a biaryl substituent. Bioorg Med Chem Lett. 2010 Jan 15;20(2):516-520.


[Related Small Molecules]

Oxytocin acetate | Carbetocin Acetate | OT-R antagonist 1 | L-368,899 hydrochloride | GSK 557296 | OT antagonist 1 | OT antagonist 3 | Retosiban

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
584.0±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C19H19ClFN5O3

[ Molecular Weight ]:
419.837

[ Flash Point ]:
307.0±32.9 °C

[ Exact Mass ]:
419.116058

[ PSA ]:
74.53000

[ LogP ]:
1.85

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.646

Related Compounds