Streptokinase

Names

[ Name ]:
Streptokinase

[Synonym ]:
L-Proline,4-cyclohexyl-,(4S)
MFCD00082037
Streptokinase
4-Cyclohexylproline
4-cyclohexyl-2-pyrrolidinecarboxylic acid
Proline, 4-cyclohexyl-

Biological Activity

[Description]:

Streptokinase is a bacteria-derived protein and a plasminogen activator. Streptokinase is widely used for the research of the blood-clotting disorders. Streptokinase improves reperfusion blood flow after coronary artery occlusion[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[In Vivo]

Sreptokinase (6000 IU/kg in 3 ml of saline; intracoronary; infused at 0.05 ml/min for 60 minutes beginning 30 minutes before reperfusion) maintains reperfusion coronary blood flow through a critical stenosis at a rate similar to baseline levels[2].

[References]

[1]. Vaughan DE, et al. Streptokinase-induced platelet aggregation. Prevalence and mechanism. Circulation. 1991;84(1):84-91.

[2]. Mickelson JK, et al. Streptokinase improves reperfusion blood flow after coronary artery occlusion. Int J Cardiol. 1989;23(3):373-384.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
343.9±35.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₁H₁₉NO₂

[ Molecular Weight ]:
197.274

[ Flash Point ]:
161.8±25.9 °C

[ Exact Mass ]:
197.141586

[ PSA ]:
49.33000

[ LogP ]:
1.99

[ Appearance of Characters ]:
lyophilized powder

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.517

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OB8880000

CHEMICAL NAME :: Kinase (enzyme-activating), strepto-

CAS REGISTRY NUMBER :: 9002-01-1

LAST UPDATED :: 199512

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Human

DOSE/DURATION :: 600 iu/kg

TOXIC EFFECTS :: Immunological Including Allergic - uncharacterized

REFERENCE :: JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 252,1314,1984

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 562500 iu/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 252,1314,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 43,671,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FOHEAW Folia Haematologica (Leipzig). (Buchexport, Postfach 160, Leipzig DDR-7010, Ger. Dem. Rep.) V.32- 1926- Volume(issue)/page/year: 103,445,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FOHEAW Folia Haematologica (Leipzig). (Buchexport, Postfach 160, Leipzig DDR-7010, Ger. Dem. Rep.) V.32- 1926- Volume(issue)/page/year: 103,445,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 43,671,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4087 No. of Facilities: 41 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 9366 (estimated) No. of Female Employees: 8266 (estimated)

Safety Information

[ Hazard Codes ]:
C,Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
22-24/25-36-26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
OB8880000

Preparation

Articles

Staphylokinase, a fibrin-specific plasminogen activator with therapeutic potential?

Blood 84 , 680-6, (1994)

Primary coronary intervention versus thrombolytic therapy in myocardial infarction patients in the Middle East Al-Zakwani, I., et al.

J. Am. Med. Assoc. 34(3) , 445-51, (2012)

Effects of plasminogen and streptokinase on the vital functions of nervous tissue cells in culture Nikandrov, V., et al.

Biomed. Khim. 54 , 192-200, (2012)

Related Compounds

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