Ribonuclease A

Names

[ Name ]:
Ribonuclease A

[Synonym ]:
Ribonuclease A
MFCD00132181
2-[(3-Aminopropanoyl)amino]-3-(1H-imidazol-4-yl)propanoic acid
Histidine, β-alanyl-
b-Alanylhistidine
β-Alanylhistidine
carnosine
EINECS 232-646-6
N-(3-Aminopropanoyl)histidine

Biological Activity

[Description]:

Ribonuclease A cleaves RNA 3′ to pyrimidines and actively cleaves RNA at every pyrimidine residue. Ribonuclease A catalyzes the hydrolysis of single stranded RNA in the absence of metal ions or cofactors[1][2][3].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
656.2±55.0 °C at 760 mmHg

[ Melting Point ]:
243 ºC (dec.)

[ Molecular Formula ]:
C₉H₁₄N₄O₃

[ Molecular Weight ]:
226.232

[ Flash Point ]:
350.7±31.5 °C

[ Exact Mass ]:
226.106583

[ LogP ]:
-2.17

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.591

[ Storage condition ]:
-20°C

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
RF0760000

Articles

2-Iodohexadecanal inhibits thyroid cell growth in part through the induction of let-7f microRNA.

Mol. Cell. Endocrinol. 414 , 224-32, (2015)

It is well known that pituitary TSH exerts the major task in the regulation of thyroid function. However, this gland is capable of certain degree of autonomy, independently of TSH control. Iodine play...

Electrodynamic pressure modulation of protein stability in cosolvents.

Biochemistry 52(46) , 8363-73, (2013)

Cosolvents affect structural stability of proteins in aqueous solutions. A clear understanding of the mechanism by which cosolvents impact protein stability is critical to understanding protein foldin...

Striking stabilization of Rana catesbeiana ribonuclease 3 by guanidine hydrochloride.

FEBS Lett. 587(6) , 737-42, (2013)

Unfolding by chemical denaturants and the linear extrapolation method are widely used to determine the free energy of proteins. Ribonuclease 3 from bullfrog shows an extraordinary behavior in guanidin...