1,12-dodecanedioic-d20 acid

Names

[ Name ]:
1,12-dodecanedioic-d20 acid

[Synonym ]:
Dodecanedioic-d20 acid
MFCD00053324

Biological Activity

[Description]:

Dodecanedioic acid-d20 is the deuterium labeled Dodecanedioic acid[1]. Dodecanedioic acid (C12) is a dicarboxylic acid with a metabolic pathway intermediate to those of lipids and carbohydrates[2].

[Related Catalog]:

Research Areas >> Others

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

[2]. Greco AV, et al. The metabolic effect of dodecanedioic acid infusion in non-insulin-dependent diabetic patients. Nutrition. 1998 Apr;14(4):351-7.

Chemical & Physical Properties

[ Melting Point ]:
126-128ºC(lit.)

[ Molecular Formula ]:
C₁₂H₂D₂₀O₄

[ Molecular Weight ]:
250.42400

[ Exact Mass ]:
250.27700

[ PSA ]:
74.60000

[ LogP ]:
3.05660

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Related Compounds

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