AZD 3988

Names

[ Name ]:
AZD 3988

[Synonym ]:
2H-Cyclopenta[b]furan-2-one,hexahydro-6-hydroxy
(trans-4-{4-[({5-[(3,4-difluorophenyl)amino]-1,3,4-oxadiazol-2-yl}carbonyl)amino]phenyl}cyclohexyl)acetic acid
6-Hydroxyhexahydrocyclopenta[b]furan-2-one
(trans-2,3-Dihydroxy-cyclopentyl)-essigsaeure-lacton

Biological Activity

[Description]:

AZD3988 is a diacylglycerol acyl transferase-1 (DGAT-1) inhibitor with IC50s of 6, 5, 11 nM for human, rat, mouse, respectively[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> Acyltransferase

[Target]

IC50: 6 nM (h DGAT-1), 5 nM (Rat DGAT-1), 11 nM (Mouse DGAT-1)[1]

[References]

[1]. McCoull W, et al. Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3873-8.

Chemical & Physical Properties

[ Density]:
1.402

[ Molecular Formula ]:
C₂₃H₂₂F₂N₄O₄

[ Molecular Weight ]:
456.44

[ Exact Mass ]:
456.16100

[ PSA ]:
117.35000

[ LogP ]:
5.23820

[ Index of Refraction ]:
1.627

Synthetic Route

Click to get detail synthetic route

Related Compounds

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