892489-52-0
892489-52-0 structure
- Name: AZD 3988
- Chemical Name: trans-4-[4-[[[5-[(3,4-Difluorophenyl)amino]-1,3,4-oxadiazol-2-yl]carbonyl]amino]phenyl]cyclohexaneacetic acid
- CAS Number: 892489-52-0
- Molecular Formula: C23H22F2N4O4
- Molecular Weight: 456.44
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Acyltransferase
- Create Date: 2018-12-27 18:46:42
- Modify Date: 2024-01-11 15:05:04
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AZD3988 is a diacylglycerol acyl transferase-1 (DGAT-1) inhibitor with IC50s of 6, 5, 11 nM for human, rat, mouse, respectively[1].
| Name | trans-4-[4-[[[5-[(3,4-Difluorophenyl)amino]-1,3,4-oxadiazol-2-yl]carbonyl]amino]phenyl]cyclohexaneacetic acid |
|---|---|
| Synonyms |
2H-Cyclopenta[b]furan-2-one,hexahydro-6-hydroxy
(trans-4-{4-[({5-[(3,4-difluorophenyl)amino]-1,3,4-oxadiazol-2-yl}carbonyl)amino]phenyl}cyclohexyl)acetic acid 6-Hydroxyhexahydrocyclopenta[b]furan-2-one (trans-2,3-Dihydroxy-cyclopentyl)-essigsaeure-lacton |
| Description | AZD3988 is a diacylglycerol acyl transferase-1 (DGAT-1) inhibitor with IC50s of 6, 5, 11 nM for human, rat, mouse, respectively[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 6 nM (h DGAT-1), 5 nM (Rat DGAT-1), 11 nM (Mouse DGAT-1)[1] |
| References |
| Density | 1.402 |
|---|---|
| Molecular Formula | C23H22F2N4O4 |
| Molecular Weight | 456.44 |
| Exact Mass | 456.16100 |
| PSA | 117.35000 |
| LogP | 5.23820 |
| Index of Refraction | 1.627 |
|
~80%
892489-52-0 |
| Literature: ASTRAZENECA AB; ASTRAZENECA UK LIMITED Patent: WO2007/144571 A1, 2007 ; Location in patent: Page/Page column 21-22 ; WO 2007/144571 A1 |
