S3QEL 2

Names

[ Name ]:
S3QEL 2

Biological Activity

[Description]:

S3QEL-2, a suppressor of superoxide production from mitochondrial complex III, potently and selectively suppresses site IIIQo superoxide production (IC50=1.7 μM). S3QEL-2 does not affect oxidative phosphorylation, and normal electron flux. S3QEL-2 inhibits HIF-1α accumulation[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

[In Vitro]

S3QELs-2 protects against ROS-induced, JNK-mediated cell stress in pancreatic β-cells and S3QEL-2 strongly mitigates the oxidative stress-induced apoptosis that limits the yield of functional β-cells from intact islets[1].

[References]

[1]. Orr AL, et al. Suppressors of superoxide production from mitochondrial complex III. Nat Chem Biol. 2015;11(11):834-836.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₅N₅

[ Molecular Weight ]:
323.44

Related Compounds

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