M47

Names

[ Name ]:
M47

Biological Activity

[Description]:

M47 is a small molecule that selectively destabilizes Cryptochrome 1 (CRY1) and increases degradation of the CRY1 in the nucleus. M47 enhances apoptosis in Ras-transformed P53-deficient mouse skin fibroblast lines and enhances life span in p53 knockout mice. M47 can be used in research of cancer[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[In Vitro]

M47 (0-10 μM; 0-120 h; U2OS Bmal1-dLuc 细胞) 以剂量依赖性方式降低 CRY1 的半衰期并引起昼夜节律变化[1]。 M47 (10 μM; 24-44 h) 降低 U2OS 细胞中 CRY1 的水平[1]。 Western Blot Analysis[1] Cell Line: U2OS cells Concentration: 10 μM Incubation Time: 24-44 hours Result: Decreased CRY1 protein levels between 24 and 48 h.

[In Vivo]

M47 (5-1000 mg/kg; i.p.; daily, for 5 d; C57BL/6J 小鼠和 p53 基因敲除 C57BL/6J 小鼠) 选择性地降低 CRY1 的半衰期，并且耐受性良好，在体内并增强细胞凋亡[1]。 Animal Model: C57BL/6 J mice and p53 gene knockout C57BL/6 J mice[1] Dosage: 5, 50, 300 and 1000 mg/kg Administration: intraperitoneal injection, daily, for 5 days Result: Prolonged the life span of p53 gene knockout mice.

[References]

[1]. Gul S, et, al. Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice. Nat Commun. 2022 Nov 8;13(1):6742.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₂₂ClNO₄

[ Molecular Weight ]:
471.93

Related Compounds

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