890808-56-7
890808-56-7 structure
- Name: M47
- Chemical Name: M47
- CAS Number: 890808-56-7
- Molecular Formula: C28H22ClNO4
- Molecular Weight: 471.93
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2023-04-14 14:37:35
- Modify Date: 2024-01-14 22:28:35
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M47 is a small molecule that selectively destabilizes Cryptochrome 1 (CRY1) and increases degradation of the CRY1 in the nucleus. M47 enhances apoptosis in Ras-transformed P53-deficient mouse skin fibroblast lines and enhances life span in p53 knockout mice. M47 can be used in research of cancer[1].
| Name | M47 |
|---|
| Description | M47 is a small molecule that selectively destabilizes Cryptochrome 1 (CRY1) and increases degradation of the CRY1 in the nucleus. M47 enhances apoptosis in Ras-transformed P53-deficient mouse skin fibroblast lines and enhances life span in p53 knockout mice. M47 can be used in research of cancer[1]. |
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| Related Catalog | |
| In Vitro | M47 (0-10 μM; 0-120 h; U2OS Bmal1-dLuc 细胞) 以剂量依赖性方式降低 CRY1 的半衰期并引起昼夜节律变化[1]。 M47 (10 μM; 24-44 h) 降低 U2OS 细胞中 CRY1 的水平[1]。 Western Blot Analysis[1] Cell Line: U2OS cells Concentration: 10 μM Incubation Time: 24-44 hours Result: Decreased CRY1 protein levels between 24 and 48 h. |
| In Vivo | M47 (5-1000 mg/kg; i.p.; daily, for 5 d; C57BL/6J 小鼠和 p53 基因敲除 C57BL/6J 小鼠) 选择性地降低 CRY1 的半衰期，并且耐受性良好，在体内并增强细胞凋亡[1]。 Animal Model: C57BL/6 J mice and p53 gene knockout C57BL/6 J mice[1] Dosage: 5, 50, 300 and 1000 mg/kg Administration: intraperitoneal injection, daily, for 5 days Result: Prolonged the life span of p53 gene knockout mice. |
| References |
| Molecular Formula | C28H22ClNO4 |
|---|---|
| Molecular Weight | 471.93 |