Dutogliptin tartrate

Names

[ Name ]:
Dutogliptin tartrate

[Synonym ]:
L-tartrate salt of (2R)-1-{7-[(9R)-pyrrolidin-9-ylamino]-acetyl}-pyrrolidine-2-boronic acid
dutogliptin

Biological Activity

[Description]:

Dutogliptin tartrate (PHX-1149) is an orally available, potent, and selective dipeptidyl peptidase-4 (DPP4) inhibitor for the treatment of type 2 diabetes mellitus.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Dipeptidyl Peptidase

Research Areas >> Metabolic Disease

[Target]

DPP4[1]

[In Vivo]

Dutogliptin exhibits low plasma protein binding (11%) and is rapidly absorbed with a Tmax of 3-4 h and a half-life of 10-13 h. Dutogliptin is metabolically stable and does not inhibit or induce the activity of major CYP450s[2].

[References]

[1]. Marier JF, et al. Population pharmacokinetic analysis of dutogliptin, a selective dipeptidyl peptidase-4 inhibitor. Clin Pharmacol Drug Dev. 2014 Jul;3(4):297-304.

[2]. Pattzi HM, et al. Dutogliptin, a selective DPP4 inhibitor, improves glycaemic control in patients with type 2 diabetes: a 12-week, double-blind, randomized, placebo-controlled, multicentre trial. Diabetes Obes Metab. 2010 Apr;12(4):348-55.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₂₆BN₃O₉

[ Molecular Weight ]:
391.18200

[ Exact Mass ]:
391.17600

[ PSA ]:
199.89000

Related Compounds

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