Bafilomycin B1
Names
[ CAS No. ]:
88899-56-3
[ Name ]:
Bafilomycin B1
[Synonym ]:
(5R)-2,4-Dideoxy-1-C-{(2S,3R,4S)-3-hydroxy-4-[(3S,4Z,9S,10S,11R)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-2-pentanyl}-3-O-{(2E)-4-[(2-hydroxy-5-ox ;o-1-cyclopenten-1-yl)amino]-4-oxo-2-butenoyl}-5-isopropyl-4-methyl-α-D-threo-pentopyranose
BAFILOMYCIN B1 MONOHYDRATE FROM STREPTO-MYCES SPECIES
bafilomycin b1from streptomyces sp.
α-D-threo-Pentopyranose, 2,4-dideoxy-1-C-[(1S,2R,3S)-2-hydroxy-3-[(3S,4Z,9S,10S,11R)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-3 -O-[(2E)-4-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-1,4-dioxo-2-buten-1-yl]-4-methyl-5-C-(1-methylethyl)-, (5R)-
ino)carbonyl)-2-methoxy-24-methyl
BafilomycinB1fromStreptomycesgriseus
MFCD00214150
Biological Activity
[Description]:
[Related Catalog]:
[References]
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
939.4±65.0 °C at 760 mmHg
[ Molecular Formula ]:
C44H65NO13
[ Molecular Weight ]:
815.986
[ Flash Point ]:
521.9±34.3 °C
[ Exact Mass ]:
815.445618
[ PSA ]:
207.38000
[ LogP ]:
3.06
[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C
[ Index of Refraction ]:
1.563
[ Storage condition ]:
−20°C
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- NG8841000
- CHEMICAL NAME :
- Hygrolidin, 37-decarboxy-2-demethyl-37-(((2-hydroxy-5-oxo-1-cyclo penten-1-yl)amino)car bonyl)- 2-methoxy-24-methyl-
- CAS REGISTRY NUMBER :
- 88899-56-3
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C44-H65-N-O13
- MOLECULAR WEIGHT :
- 816.10
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1250 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 34,1253,1981
Safety Information
[ Symbol ]:
GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H300 + H310 + H330
[ Precautionary Statements ]:
P260-P264-P280-P284-P301 + P310-P302 + P350
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ Hazard Codes ]:
T+: Very toxic;
[ Risk Phrases ]:
R26/27/28
[ Safety Phrases ]:
36/37/39-45
[ RIDADR ]:
UN 3462 6.1/PG 1
[ WGK Germany ]:
3
[ RTECS ]:
NG8841000
Precursor & DownStream
Precursor
DownStream
Articles
Proc. Natl. Acad. Sci. U. S. A. 85 , 7972, (1988)
Various membrane ATPases have been tested for their sensitivity to bafilomycin A1, a macrolide antibiotic. F1F0 ATPases from bacteria and mitochondria are not affected by this antibiotic. In contrast,...
Inhibition of the accumulation of lipid droplets in macrophage J774 by bafilomycin B1 and destruxin E.Biochim. Biophys. Acta 1126(1) , 41-8, (1992)
Two microbial metabolites, bafilomycin B1 and destruxin E, have been found to inhibit significantly the oxidized low density lipoprotein (LDL)-induced accumulation of lipid droplets at 3 nM and 0.5 mi...
The plecomacrolide vacuolar-ATPase inhibitor bafilomycin, alters insulin signaling in MIN6 beta-cells.Cell Biol. Toxicol. 22(3) , 169-81, (2006)
Inhibition of endosomal acidification disturbs insulin signaling in both liver and adipose cells. In this study we used MIN6 beta cells to determine whether bafilomycin, a potent inhibitor of the prot...