Isogambogenic acid

Names

[ Name ]:
Isogambogenic acid

[Synonym ]:
(2E)-4-[(2S,13S)-7-[(2E)-3,7-Dimethyl-2,6-octadien-1-yl]-6,8-dihydroxy-17,17-dimethyl-5-(3-methyl-2-buten-1-yl)-10,14-dioxo-3,16-dioxapentacyclo[11.4.1.02,11.02,15.04,9]octadeca-4,6,8,11-tetraen -15-yl]-2-methyl-2-butenoic acid
2-Butenoic acid, 4-[(5S,12aS)-9-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-3a,4,5,7-tetrahydro-8,10-dihydroxy-3,3-dimethyl-11-(3-methyl-2-buten-1-yl)-7,13-dioxo-1,5-methano-1H,3H-furo[3,4-d]xanthen-1-yl]-2-methyl-, (2E)-

Biological Activity

[Description]:

Isogambogenic acid is a natural product that can be isolated from Resina Garciniae. Isogambogenic acid has cytotoxicity to cancer cell lines with IC50 values of 0.4327-5.942 μmol/L[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vitro]

Isogambogenic acid (20-68 h) 对 HL-60、SMMC-7721 和 BGC-83 细胞的 IC50 值分别为 0.1544、5.942 和 0.04327 μmol/L[1]。

[References]

[1]. Feng F, et al. Five novel prenylated xanthones from Resina Garciniae. J Asian Nat Prod Res. 2007 Sep-Dec;9(6-8):735-41.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
818.6±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₈H₄₆O₈

[ Molecular Weight ]:
630.767

[ Flash Point ]:
253.0±27.8 °C

[ Exact Mass ]:
630.319275

[ LogP ]:
9.42

[ Vapour Pressure ]:
0.0±3.1 mmHg at 25°C

[ Index of Refraction ]:
1.619

Related Compounds

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