Cilazapril

Names

[ Name ]:
Cilazapril

[Synonym ]:
Ro 34-2848
(1S,9S)-9-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid
9(S)-[1-(S)-(ethoxycarbony)-3-phenylpropylamino]octahydro-10-oxo-6H-pyridazo[1,2-a][1,2]-diazepine-1(S)-carboxylic acid
(1S,9S)-9-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-10-oxooctahydro-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid
Cilazaprilum [Latin]
Cilazaprilum
MFCD08459332
Cilazil
EINECS 279-694-4
Cilazapril

Biological Activity

[Description]:

Cilazapril is a angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and congestive heart failure.Target: ACECilazapril is a new nonthiol group containing angiotensin converting enzyme (ACE) inhibitor. Cilazapril has been investigated in more than 4000 patients with all degrees of hypertension, as well as in the special patient groups such as the elderly, renally impaired, and patients with concomitant diseases, such as congestive cardiac failure or chronic obstructive pulmonary disease [1]. Cilazapril is a very potent and highly effective converting enzyme inhibitor. Doses well below 5 mg/day will probably suffice for therapeutic efficacy [2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)

Research Areas >> Cardiovascular Disease

[References]

[1]. Szucs, T., Cilazapril. A review. Drugs, 1991. 41 Suppl 1: p. 18-24.

[2]. Nussberger, J., et al., Repeated administration of the converting enzyme inhibitor cilazapril to normal volunteers. J Cardiovasc Pharmacol, 1987. 9(1): p. 39-44.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.26g/cm3

[ Boiling Point ]:
598.1ºC at 760 mmHg

[ Melting Point ]:
95-97ºC

[ Molecular Formula ]:
C₂₂H₃₁N₃O₅

[ Molecular Weight ]:
417.49900

[ Flash Point ]:
315.5ºC

[ Exact Mass ]:
417.22600

[ PSA ]:
99.18000

[ LogP ]:
1.86220

[ Vapour Pressure ]:
3.73E-15mmHg at 25°C

[ Index of Refraction ]:
1.591

[ Storage condition ]:
2-8°C

Safety Information

[ Safety Phrases ]:
22-24/25

[ RTECS ]:
MJ9650200

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.