Togni's Reagent
Names
[ CAS No. ]:
887144-97-0
[ Name ]:
Togni's Reagent
[Synonym ]:
MFCD10567056
Togni's Reagent
1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole
3,3-Dmethyl-1-(trifluoromethyl)-1,2-benziodoxole
3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole
Togni's Reagent: dimethyl compound
3,3-Dimethyl-1-(trifluoromethyl)-1,3-dihydro-1λ,2-benziodoxole
UNII:3OK0E02MT6
3,3-dimethyl-1-(trifluoromethyl)-1λ<sup>3</sup>,2-benziodoxole
Chemical & Physical Properties
[ Melting Point ]:
75-79ºC
[ Molecular Formula ]:
C10H10F3IO
[ Molecular Weight ]:
330.086
[ Exact Mass ]:
329.972839
[ PSA ]:
9.23000
[ LogP ]:
4.06270
MSDS
Safety Information
[ Symbol ]:
GHS02, GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H228-H315-H319-H335
[ Precautionary Statements ]:
P210-P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi: Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
26-36/37
[ RIDADR ]:
UN1325 - class 4.1 - PG 3 - Flammable solids, organic, n.o.s., HI: all
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Angew. Chem. Int. Ed. Engl. 5th ed., 50 , 1059-1063, (2011)
The productive merger of iodonium salts and organocatalysis: a non-photolytic approach to the enantioselective alpha-trifluoromethylation of aldehydes.
J. Am. Chem. Soc. 132 , 4986-4987, (2010)
An enantioselective organocatalytic alpha-trifluoromethylation of aldehydes has been accomplished using a commercially available, electrophilic trifluoromethyl source. The merging of Lewis acid and or...
Pd(II)-catalyzed ortho-trifluoromethylation of arenes using TFA as a promoter.J. Am. Chem. Soc. 11th ed., 132 , 3648-3649, (2010)
A Pd(II)-catalyzed C-H activation/trifluoromethylation of arenes with an electrophilic trifluoromethylation reagent using diverse heterocycle directing groups is reported. The presence of trifluoroace...