Journal of the American Chemical Society 2010-03-24

Pd(II)-catalyzed ortho-trifluoromethylation of arenes using TFA as a promoter.

Xisheng Wang, Larry Truesdale, Jin-Quan Yu

Index: J. Am. Chem. Soc. 11th ed., 132 , 3648-3649, (2010)

Full Text: HTML

Abstract

A Pd(II)-catalyzed C-H activation/trifluoromethylation of arenes with an electrophilic trifluoromethylation reagent using diverse heterocycle directing groups is reported. The presence of trifluoroacetic acid is crucial for this catalytic reaction.

Related Compounds

Related Articles:

A Ritter-type reaction: direct electrophilic trifluoromethylation at nitrogen atoms using hypervalent iodine reagents.

2011-02-01

[Angew. Chem. Int. Ed. Engl. 5th ed., 50 , 1059-1063, (2011)]

The productive merger of iodonium salts and organocatalysis: a non-photolytic approach to the enantioselective alpha-trifluoromethylation of aldehydes.

2010-04-14

[J. Am. Chem. Soc. 132 , 4986-4987, (2010)]

Copper-catalyzed trifluoromethylation of aryl and vinyl boronic acids with an electrophilic trifluoromethylating reagent.

2011-05-06

[Org. Lett. 13 , 2342-2345, (2011)]

Highly selective trifluoromethylation of 1,3-disubstituted arenes through iridium-catalyzed arene borylation.

2012-01-09

[Angew. Chem. Int. Ed. Engl. 2nd ed., 51 , 540-543, (2012)]

Direct electrophilic N-trifluoromethylation of azoles by a hypervalent iodine reagent.

2012-06-25

[Angew. Chem. Int. Ed. Engl. 26th ed., 51 , 6511-6515, (2012)]

More Articles...