Tricaine methanesulfonate

Names

[ CAS No. ]:
886-86-2

[ Name ]:
Tricaine methanesulfonate

[Synonym ]:
Ethyl 3-aminobenzoate methanesulfonate salt
Ethyl 3-aminobenzoate methanesulfonate
Benzoic acid, 3-amino-, ethyl ester, methanesulfonate (1:1)
Ethyl 3-aminobenzoate methanesulfonate (1:1)
Ethyl m-aminobenzoate methanesulfonate
ethyl 3-aminobenzoate,methanesulfonic acid
Benzoic acid, m-amino-, ethyl ester, methanesulfonate
Ethyl 3-aminobenzoate methanesulphonate salt
EINECS 212-956-8
MFCD00013176
Tricaine methansulphate
Tricaine mesylate

Biological Activity

[Description]:

Tricaine methanesulfonate (MS-222) possesses anesthetic effect. Tricaine methanesulfonate (MS-222) is common used to immobilize fish for marking or transport and to suppress sensory systems during invasive procedures[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[In Vitro]

Tricaine methanesulfonate in powder form easily can become airborne and could become hazardous to the handler[1]. Tricaine methanesulfonate (TMS) solution is photosensitive (its color changes with light exposure), although the color change does not necessarily indicate significant activity decrease and thus color should not be used to gauge degradation[1].

[References]

[1]. Kathleen M. Carter, et al. A review of tricaine methanesulfonate for anesthesia of fish. Reviews in Fish Biology and Fisheries volume 21, pages51–59(2011).

Chemical & Physical Properties

[ Boiling Point ]:
305-310

[ Melting Point ]:
146-149 °C(lit.)

[ Molecular Formula ]:
C₁₀H₁₅NO₅S

[ Molecular Weight ]:
261.295

[ Flash Point ]:
151.2ºC

[ Exact Mass ]:
261.067108

[ PSA ]:
115.07000

[ LogP ]:
2.61150

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
H2O: 50 mg/mL, clear, colorless

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG2455000

CHEMICAL NAME :: Benzoic acid, 3-amino-, ethyl ester, methanesulfonate

CAS REGISTRY NUMBER :: 886-86-2

LAST UPDATED :: 199710

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C9-H11-N-O2.C-H4-O3-S

MOLECULAR WEIGHT :: 261.32

WISWESSER LINE NOTATION :: ZR CVO2 &WSQ1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#03233

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic

REFERENCE :: PHMCAA Pharmacologist. (American Soc. for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1959- Volume(issue)/page/year: 16,252,1974

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DG2455000

[ HS Code ]:
2923900090

Customs

[ HS Code ]: 2923900090

[ Summary ]:
2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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Related Compounds

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