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Larsucosterol

Names

[ CAS No. ]:
884905-07-1

[ Name ]:
Larsucosterol

[Synonym ]:
(3β)-25-Hydroxycholest-5-en-3-yl hydrogen sulfate
Cholest-5-ene-3,25-diol, 3-(hydrogen sulfate), (3β)-

Biological Activity

[Description]:

Larsucosterol is a cholesterol metabolite from the nuclei of normal human liver tissues, epigenetically regulates the transcription of proteins and enzymes involved in lipid synthesis, inflammation, and apoptosis[1][2].

[Related Catalog]:

Research Areas >> Metabolic Disease

[References]

[1]. Ren S, Hylemon P, Zhang ZP, Rodriguez-Agudo D, Marques D, Li X, Zhou H, Gil G, Pandak WM. Identification of a novel sulfonated oxysterol, 5-cholesten-3beta,25-diol 3-sulfonate, in hepatocyte nuclei and mitochondria. J Lipid Res. 2006 May;47(5):1081-90. doi: 10.1194/jlr.M600019-JLR200. Epub 2006 Feb 27. PMID: 16505492.

[2]. Wang Y, Li X, Ren S. Cholesterol Metabolites 25-Hydroxycholesterol and 25-Hydroxycholesterol 3-Sulfate Are Potent Paired Regulators: From Discovery to Clinical Usage. Metabolites. 2020 Dec 25;11(1):9.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Molecular Formula ]:
C27H46O5S

[ Molecular Weight ]:
482.72

[ Exact Mass ]:
482.306610

[ LogP ]:
7.95

[ Index of Refraction ]:
1.552

[ Storage condition ]:
-20°C

Related Compounds