CMP-5

Names

[ Name ]:
CMP-5

[Synonym ]:
9H-Carbazole-3-methanamine, 9-ethyl-N-(2-pyridinylmethyl)-
1-(9-Ethyl-9H-carbazol-3-yl)-N-(2-pyridinylmethyl)methanamine

Biological Activity

[Description]:

CMP-5 (PRMT5-IN-5)is a first-in-class, small-molecule PRMT5-specific inhibitor that blocks EBV-driven B-lymphocyte transformation and survival, without effect on normal B cells; displays no activity against other type I (PRMT1 and PRMT4) and type II (PRMT7) enzymes; inhibition of PRMT5 leads to lost recruitment of a PRMT5/p65/HDAC3-repressive complex on the miR96 promoter, restored miR96 expression, and PRMT5 downregulation.

[References]

References 1. Alinari L, et al. Blood. 2015 Apr 16;125(16):2530-43. View Related Products by Target Histone Methyltransferase (HMTase)

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
505.1±48.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₁N₃

[ Molecular Weight ]:
315.411

[ Flash Point ]:
259.3±29.6 °C

[ Exact Mass ]:
315.173553

[ LogP ]:
4.23

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.637

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.