CMP-5 hydrochloride

Names

[ Name ]:
CMP-5 hydrochloride

[Synonym ]:
9H-Carbazole-3-methanamine, 9-ethyl-N-(2-pyridinylmethyl)-, hydrochloride (1:1)
1-(9-Ethyl-9H-carbazol-3-yl)-N-(2-pyridinylmethyl)methanamine hydrochloride (1:1)

Biological Activity

[Description]:

CMP-5 (PRMT5-IN-5)is a first-in-class, small-molecule PRMT5-specific inhibitor that blocks EBV-driven B-lymphocyte transformation and survival, without effect on normal B cells; displays no activity against other type I (PRMT1 and PRMT4) and type II (PRMT7) enzymes; inhibition of PRMT5 leads to lost recruitment of a PRMT5/p65/HDAC3-repressive complex on the miR96 promoter, restored miR96 expression, and PRMT5 downregulation.

[References]

References 1. Alinari L, et al. Blood. 2015 Apr 16;125(16):2530-43. View Related Products by Target Histone Methyltransferase (HMTase)

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₂ClN₃

[ Molecular Weight ]:
351.872

[ Exact Mass ]:
351.150238

Related Compounds

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