JNJ 303

Names

[ Name ]:
JNJ 303

[Synonym ]:
jnj 303

Biological Activity

[Description]:

JNJ 303 is a potent IKs blocker with an IC50 value of 64 nM. JNJ 303 does not have any effects on other cardiac channels at concentrations of 3.3 μM for INa, Ica, Ito, and IKr. JNJ 303 induces QT-prolongations and causes unprovoked torsades de pointes (TdP)[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[Target]

IC50: 64 nM (IKs)[1]

[References]

[1]. Julie Albrecht, et al. The effect of the KV7/KCNE 1 inhibitor JNJ 303 on heart slices and the L-type calcium channel of cardiac cells.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₉ClN₂O₄S

[ Molecular Weight ]:
440.98400

[ Exact Mass ]:
440.15400

[ PSA ]:
96.37000

[ LogP ]:
5.42210

Related Compounds

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