JNJ-42905343

Names

[ Name ]:
JNJ-42905343

Biological Activity

[Description]:

JNJ-42905343 is a potent, selective, orally active prolyl hydroxylase (PHD) inhibitor with pKi of 8.07, 7.48 and 7.27 for PHD1, PHD2 and PHD3 respectively; stabilizes HIF1-α in a concentration-dependent fashion in HeLa cells (EC50=19.7 uM) and stimulates the release of EPO from Hep3B cells (EC50=20.3 uM); increases blood haemoglobin, mean corpuscular haemoglobin (MCH) and mean corpuscular volume (MCV), corrects functional iron deficiency and inflammation-induced anaemia in rats.

[References]

References 1. Barrett TD, et al. Br J Pharmacol. 2015 Aug;172(16):4078-88. View Related Products by Target HIF/HIF Prolyl-hydroxylase

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₁₅FN₄O₄

[ Molecular Weight ]:
394.362

Related Compounds

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