Indomethacin-D4

Names

[ Name ]:
Indomethacin-D4

Biological Activity

[Description]:

Indomethacin-D4 (Indometacin-D4) is a deuterium labeled Indomethacin. Indomethacin is a potent and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells[1].

[Related Catalog]:

Signaling Pathways >> Autophagy >> Autophagy

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Immunology/Inflammation >> COX

[Target]

Human COX-1:18 nM (IC50, in CHO cells)

Human COX-2:26 nM (IC50, in CHO cells)

[References]

[1]. Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₁₂D₄ClNO₄

[ Molecular Weight ]:
361.81200

[ Exact Mass ]:
361.10200

[ PSA ]:
68.53000

[ LogP ]:
3.92730

Related Compounds

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