NSCI

Names

[ CAS No. ]:
872254-32-5

[ Name ]:
NSCI

[Synonym ]:
Pyridine Analogue 21c

Biological Activity

[Description]:

Caspase-3-IN-1 (compound 11b) is a potent Caspase-3 inhibitor, with an IC50 of 14.5 nM[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Caspase

Research Areas >> Metabolic Disease

Research Areas >> Neurological Disease

[Target]

Caspase-3:14.5 ± 1.6 nM (IC50)

Caspase-7:21.8 ± 3.5 nM (IC50)

Caspase-6:>5000 nM (IC50)

Caspase-1:>10000 nM (IC50)

Caspase-8:>50000 nM (IC50)

[References]

[1]. Chu W, et al. N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: synthesis, in vitro activity, and molecular modeling studies. J Med Chem. 2005 Dec 1;48(24):7637-47.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₂₅N₃O₆S

[ Molecular Weight ]:
507.55800

[ Exact Mass ]:
507.14600

[ PSA ]:
114.49000

[ LogP ]:
4.13550

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Structural insight on the control of urea synthesis: identification of the binding site for N-acetyl-L-glutamate, the essential allosteric activator of mitochondrial carbamoyl phosphate synthetase.

Biochem. J. 424 , 211-20, (2009)

NAG (N-acetyl-L-glutamate), the essential allosteric activator of the first urea cycle enzyme, CPSI (carbamoyl phosphate synthetase I), is a key regulator of this crucial cycle for ammonia detoxificat...

Related Compounds

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