TCMDC-125457

Names

[ Name ]:
TCMDC-125457

Biological Activity

[Description]:

TCMDC-125457 is potent in inducing calcium redistribution but minimally inhibits heme crystallization. TCMDC-125457 demonstrated high efficacy when pulsed in a single-dose combination with artesunate against tightly synchronized artemisinin-resistant ring-stage parasites.

[References]

[1]. Chia W, et al. High-Content Phenotypic Screen of a Focused TCAMS Drug Library Identifies Novel Disruptors of the Malaria Parasite Calcium Dynamics. ACS Chem Biol. 2021 Nov 19;16(11):2348-2372.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₁₈ClN₅O₃

[ Molecular Weight ]:
399.83

Related Compounds

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