AL-9

AL-9 is a small molecule HCV replication inhibitor with EC50 of 0.29 and 0.75 uM for genotype 1b and 2a, inhibits purified PI4KIIIα with IC50 of 0.57 uM; inhibits HCV across different genotypes with activity in the sub-micromolar to low micromolar range in the absence of significant cytotoxic effects; inhibits PI4KIIIα also in living cells, while not appreciably affecting the activity of PI4KIIIβ, does not affect the level of PI4P in the Golgi membrane.

References 1. Bianco A, et al. PLoS Pathog. 2012;8(3):e1002576. 2. MacLeod AM, et al. ACS Med Chem Lett. 2013 May 8;4(7):585-9. View Related Products by Target HCV