869218-90-6
869218-90-6 structure
- Name: AL-9
- Chemical Name: AL-9
- CAS Number: 869218-90-6
- Molecular Formula: C23H22N4O3
- Molecular Weight: 402.454
- Catalog: Signaling Pathways Anti-infection HCV
- Create Date: 2020-01-13 14:23:01
- Modify Date: 2024-09-12 17:59:48
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AL-9 is a small molecule HCV replication inhibitor with EC50 of 0.29 and 0.75 uM for genotype 1b and 2a, inhibits purified PI4KIIIα with IC50 of 0.57 uM; inhibits HCV across different genotypes with activity in the sub-micromolar to low micromolar range in the absence of significant cytotoxic effects; inhibits PI4KIIIα also in living cells, while not appreciably affecting the activity of PI4KIIIβ, does not affect the level of PI4P in the Golgi membrane.
| Name | AL-9 |
|---|
| Description | AL-9 is a small molecule HCV replication inhibitor with EC50 of 0.29 and 0.75 uM for genotype 1b and 2a, inhibits purified PI4KIIIα with IC50 of 0.57 uM; inhibits HCV across different genotypes with activity in the sub-micromolar to low micromolar range in the absence of significant cytotoxic effects; inhibits PI4KIIIα also in living cells, while not appreciably affecting the activity of PI4KIIIβ, does not affect the level of PI4P in the Golgi membrane. |
|---|---|
| References | References 1. Bianco A, et al. PLoS Pathog. 2012;8(3):e1002576. 2. MacLeod AM, et al. ACS Med Chem Lett. 2013 May 8;4(7):585-9. View Related Products by Target HCV |
| Molecular Formula | C23H22N4O3 |
|---|---|
| Molecular Weight | 402.454 |