Cantuzumab ravtansine

Names

[ CAS No. ]:
868747-45-9

[ Name ]:
Cantuzumab ravtansine

Biological Activity

[Description]:

Cantuzumab ravtansine (IMGN242; huC242-DM4), an ADC, is a humanized monoclonal antibody, huC242, covalently linked via a disulfide bond to DM4 (DM4 (HY-12454)). Cantuzumab ravtansine has broad antitumor efficacy against a range of CanAg-positive human tumor xenografts[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin
Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[In Vitro]

Cantuzumab ravtansine（huC242-DM4；5 天）在 CanAg 阳性 SNU16 胃癌细胞中表现出细胞毒性作用[2]。

[In Vivo]

Cantuzumab ravtansine（huC242-DM4；静脉注射；3.4 mg/kg；单剂量）可使携带 N87 人胃肿瘤异种移植物的 SCID 小鼠的肿瘤完全消退，在低于 2 mg/kg 的剂量下观察到显着的肿瘤消退 [1]。 Cantuzumab ravtansine (huC242-DM4) 在携带人结肠肿瘤异种移植物 HT29 和 COLO 205 细胞的小鼠中也有疗效，且无毒副作用[1]。

[References]

[1]. Robert J. Lutz, et al. HuC242-DM4, an antibody-maytansinoid conjugate with superior preclinical activity in human CanAg-positive tumor xenograft models in SCID mice. Cancer Res (2005) 65 (9_Supplement): 334-335.

[2]. Olga Ab, et al. Activity of huC242-DM4, an antibody-cytotoxic agent conjugate, used in combination with anti-neoplastic agents against gastric cancer cells in culture. Mol Cancer Ther (2007) 6 (11_Supplement): A127.

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds

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