pyrimorph

Pyrimorph is a fungicide with excellent antifungal activity against oomycetes[1].

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

Pyrimorph inhibits different stages in the life cycle of P.capsici: mycelial growth (EC50 = 1.84 μg/mL), sporangia formation (EC50 = 0.17 μg/mL), zoospore release (EC50 = 4.92 μg/mL), cystospore germination (EC50 = 0.09 μg/mL)[1]. Pyrimorph exhibits 40.95% inhibition of oxygen consumption of intact mycelia at 100 μg/mL[1]. Pyrimorph inhibits the synthesis of cell wall either directly or indirectly from ultrastructural transformation of cell wall thickening and disruption of vacuoles[1].

Pyrimorph (0-28 mg/L; exposure; 0-192 h) has low toxicity and accumulates quickly in zebrafish[2]. Animal Model: Zebrafish (Brachydanio rerio), with an average body weight and length of about 0.30±0.10 g and 3.00±0.50 cm, respectively[2] Dosage: 0-28 mg/L Administration: Exposure, 0-192 h Result: Had low toxicity to zebrafish, with LC50 values ranging from 24.33 mg/L (24 h) to 19.79 mg/L (96 h). Accumulated in fish shortly.

[1]. Xiaojing Yan, et al. Study of inhibitory effects and action mechanism of the novel fungicide pyrimorph against Phytophthora capsici. J Agric Food Chem. 2010 Mar 10;58(5):2720-5.

[2]. Chunqing Zhao, et al. Acute toxicity and bioconcentration of pyrimorph in zebrafish, Brachydanio rerio. Pest Manag Sci. 2011 Sep;67(9):1178-83.