Benzyl-PEG5-azide

Names

[ Name ]:
Benzyl-PEG5-azide

[Synonym ]:
16-Azido-1-phenyl-2,5,8,11,14-pentaoxahexadecane
2,5,8,11,14-Pentaoxahexadecane, 16-azido-1-phenyl-
Benzyl-PEG5-azide

Biological Activity

[Description]:

Benzyl-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₂₇N₃O₅

[ Molecular Weight ]:
353.413

[ Exact Mass ]:
353.195068

[ LogP ]:
0.82

Benzyl-PEG5-azide

Names

Biological Activity

Chemical & Physical Properties

Related Compounds