Tecarfarin

Names

[ Name ]:
Tecarfarin

[Synonym ]:
tecarfarin
ati-5923
unii-wn1479yt50

Biological Activity

[Description]:

Tecarfarin (ATI-5923) is an orally active and non-competitive vitamin K epoxide reductase (VKOR) antagonist, and impairs the activation of the vitamin K-dependent clotting factors II, VII, IX and X[1]. Tecarfarin has the antithrombotic activity [2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

[Target]

VKOR[1]

[References]

[1]. Hobl EL, et al. Tecarfarin: A Novel Vitamin K Antagonist. Thromb Haemost. 2017 Nov;117(11):2009-2011.

[2]. Bowersox SS, et al. Antithrombotic activity of the novel oral anticoagulant, Tecarfarin [Sodium 3-[4-((1,1,1,3,3,3-hexafluoro-2-methylpropan-2-yloxy) carbonyl) benzyl]-2-oxo-2H-chromen-4-olate] in animal models. Thromb Res. 2010 Nov;126(5):e383-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₁₄F₆O₅

[ Molecular Weight ]:
460.32300

[ Exact Mass ]:
460.07500

[ PSA ]:
76.74000

[ LogP ]:
5.12950

Related Compounds

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