N3-C5-NHS ester

Names

[ Name ]:
N3-C5-NHS ester

[Synonym ]:
6-azidohexanoic acid N-hydroxysuccinimide ester
6-azidohexanoic acid succinimidyl ester
2,5-dioxopyrrolidin-1-yl 6-azidohexanoate
2,5-Pyrrolidinedione,1-[(6-azido-1-oxohexyl)oxy]
N-(6-azidohexanoyl)succinimide
succinimidyl 6-azidohexanoate

Biological Activity

[Description]:

N3-C5-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

[Related Catalog]:

Research Areas >> Cancer

[Target]

Noncleavable

[References]

[1]. Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers. J Med Chem. 2017 Dec 14;60(23):9490-9507.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₁₄N₄O₄

[ Molecular Weight ]:
254.24300

[ Exact Mass ]:
254.10200

[ PSA ]:
113.43000

[ LogP ]:
0.85496

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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