guanosine-3',5'-cyclic monophosphorothioate, sp-isomer sodium salt

Names

[ Name ]:
guanosine-3',5'-cyclic monophosphorothioate, sp-isomer sodium salt

[Synonym ]:
SP-GUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE TRIETHYLAMINE
SP-CYCLIC 3',5'-HYDROGEN PHOSPHOROTHIOATE GUANOSINE TRIETHYLAMINE
SP-CGMPS TRIETHYLAMINE
SP-CGMPS NA
sp-cgmps triethylammonium salt
SP-CGMPS SODIUM SALT
CGMPS NA SP-ISOMER
SP-CYCLIC 3'5'-HYDROGEN PHOSPOROTHIOATE GUANOSINE TRIETHYLAMINE
SP-CGMPS,TEA
GUANOSINE-3',5'-CYCLIC MONOPHOSPHOTHIOATE,SP-ISOMER SODIUM SALT

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₂₇N₆O₆PS

[ Molecular Weight ]:
462.46100

[ Exact Mass ]:
462.14500

[ PSA ]:
202.88000

[ LogP ]:
1.17220

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Inhibition of cGMP-dependent protein kinase by (Rp)-guanosine 3',5'-monophosphorothioates.

FEBS Lett. 263 , 47-50, (1990)

The activation of the cGMP-dependent protein kinase and cAMP-dependent protein kinase by the diastereomers of guanosine 3',5'-monophosphorothioate, (Sp)-cGMPS and (Rp)-cGMPS, and 8-chloroguanosine 3',...

Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K channel by cGMP-dependent protein kinase.

Proc. Natl. Acad. Sci. U. S. A. 91 , 7583-7587, (1994)

Nitric oxide (NO)-induced relaxation is associated with increased levels of cGMP in vascular smooth muscle cells. However, the mechanism by which cGMP causes relaxation is unknown. This study tested t...