N-Methylcalycinine

Names

[ Name ]:
N-Methylcalycinine

[Synonym ]:
N-methylfissoldine
(7aR)-10-Methoxy-7-methyl-6,7,7a,8-tetrahydro-5H-[1,3]benzodioxolo[6,5,4-de]benzo[g]quinolin-12-ol
N-methylcalycinine
4-Dimethylamino-benzaldoxim-N-methylaether
<4-Dimethylamino-benzyliden>-methylamin-N-oxyd
5H-1,3-Benzodioxolo[6,5,4-de]benzo[g]quinolin-12-ol, 6,7,7a,8-tetrahydro-10-methoxy-7-methyl-, (7aR)-

Biological Activity

[Description]:

N-Methylcalycinine is a nature product with AChE inhibitory activity. N-Methylcalycinine can be isolated from the roots of Stephania epigaea. N-Methylcalycinine can be used for the research of asthma, cancer, dysentery, fever, hyperglycemia, intestinal complaints, inflammation, sleep disturbances, tuberculosis and so on[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Research Areas >> Inflammation/Immunology

Research Areas >> Metabolic Disease

Signaling Pathways >> Neuronal Signaling >> AChE

[References]

[1]. Dong JW, et al. Proaporphine and aporphine alkaloids with acetylcholinesterase inhibitory activity from Stephania epigaea. Fitoterapia. 2015 Jul;104:102-7.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
531.9±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₁₉NO₄

[ Molecular Weight ]:
325.36

[ Flash Point ]:
275.5±30.1 °C

[ Exact Mass ]:
325.131409

[ PSA ]:
51.16000

[ LogP ]:
3.55

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.654

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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