KKL-40

Names

[ Name ]:
KKL-40

[Synonym ]:
N-[5-(4-Fluorophenyl)-1,3,4-oxadiazol-2-yl]-3-(trifluoromethyl)benzamide
Benzamide, N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-3-(trifluoromethyl)-

Biological Activity

[Description]:

A small-molecule inhibitor of bacterial ribosome rescue that exhibits broad-spectrum antimicrobial activity against bacteria grown in liquid culture; exhibited exceptional antimicrobial activity against both attenuated (LVS) and fully virulent strains of F. tularensis (Schu S4) in vitro with MIC of 0.12 and 0.44 ug/mL, respectively; arrests intracellular growth of F. tularensis during all stages of infection, does not affect macrophage viability or function.

[References]

References 1. Goralski TD, et al. Antimicrob Agents Chemother. 2016 May 23;60(6):3276-82. View Related Products by Target Bacterial

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C₁₆H₉F₄N₃O₂

[ Molecular Weight ]:
351.255

[ Exact Mass ]:
351.063080

[ LogP ]:
4.43

[ Index of Refraction ]:
1.570

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.