MMAF intermediate 2

Names

[ Name ]:
MMAF intermediate 2

[Synonym ]:
Methyl N-{(2R,3R)-3-methoxy-2-methyl-3-[(2S)-2-pyrrolidinyl]propanoyl}-L-phenylalaninate hydrochloride (1:1)
L-Phenylalanine, N-[(2R,3R)-3-methoxy-2-methyl-1-oxo-3-[(2S)-2-pyrrolidinyl]propyl]-, methyl ester, hydrochloride (1:1)

Biological Activity

[Description]:

MMAF intermediate 2 is an intermediate for the synthesis of MMAF (HY-15579). MMAF (Monomethylauristatin F) is a potent inhibitor of tubulin polymerization and the cytotoxic (ADC Cytotoxin) component of classic antibody drug conjugates (ADCs), such as Vorsetuzumab mafodotin and SGN-CD19A[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1].

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₉ClN₂O₄

[ Molecular Weight ]:
384.898

[ Exact Mass ]:
384.181580

Related Compounds

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