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Gsk270822a

Names

[ CAS No. ]:
864082-23-5

[ Name ]:
Gsk270822a

Biological Activity

[Description]:

GSK270822A is a selective ROCK1 inhibitor. GSK270822A exhibits IC50 of 9nM, 1100nM, 1550nM for ROCK1, RSK1, p70S6K, respectively.

[In Vitro]

GSK270822A inhibits rat aortic ring dilation with IC50 of 76nM[1].

[References]

1. Identification and Structure-​Function Analysis of Subfamily Selective G Protein-​Coupled Receptor Kinase Inhibitors. By Homan, Kristoff T.; Larimore, Kelly M.; Elkins, Jonathan M.; Szklarz, Marta; Knapp, Stefan; Tesmer, John J. G. From ACS Chemical Biology (2015), 10(1), 310-319.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H20N4O2

[ Molecular Weight ]:
396.44


Related Compounds