(2R,3R)Methyl-2-(N-((2S,3R)-3-((9S)-9-((S)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)(Methyl)Amino)-3-Methylbutanamido)-3-Methoxy-5,10-Dimethyl-4-(Methylamino)-8-Oxoundecanoyl)Pyrrolidin-2-Yl)Propionamido)-3-Methoxy-2-Methyl-3-Phenylpropanoate

Names

[ Name ]:
(2R,3R)Methyl-2-(N-((2S,3R)-3-((9S)-9-((S)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)(Methyl)Amino)-3-Methylbutanamido)-3-Methoxy-5,10-Dimethyl-4-(Methylamino)-8-Oxoundecanoyl)Pyrrolidin-2-Yl)Propionamido)-3-Methoxy-2-Methyl-3-Phenylpropanoate

[Synonym ]:
MFCD28385900
L-Valinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-3-[[(1S)-2-methoxy-2-oxo-1-(phenylmethyl)ethyl]amino]-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-valyl-N-[(3R,4S,5S)-3-methoxy-1-{(2S)-2-[(1R,2R)-1-methoxy-3-{[(2S)-1-methoxy-1-oxo-3-phenyl-2-propanyl]amino}-2-methyl-3-oxopropyl]-1-pyrrolidinyl}-5-methyl-1-oxo-4-heptanyl]-N-methyl-L-valinamide

Biological Activity

[Description]:

Fmoc-MMAF-OMe is an anticancer agent and tubulin polymerization inhibitor with an Fmoc protecting group. The active ingredient of Fmoc-MMAF-OMe, MMAF (HY-15579), is the cytotoxic (ADC Cytotoxin) component of classic antibody drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin

Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin

Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[References]

[1].

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
1029.7±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₅₅H₇₇N₅O₁₀

[ Molecular Weight ]:
968.23

[ Flash Point ]:
576.5±34.3 °C

[ Exact Mass ]:
967.567017

[ LogP ]:
9.14

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.550

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.